
Polynucleotides & Skin Boosters
What Are Polynucleotides?
Polynucleotides (PNs) are a cutting-edge skin regenerative treatment derived from purified fragments of DNA, often sourced from salmon or trout. These naturally occurring molecules stimulate the skin’s ability to repair, regenerate, and deeply hydrate itself—making them a powerful option for skin rejuvenation and healing.
When introduced into the skin through precise injections or advanced techniques, polynucleotides work by:
Boosting fibroblast activity – encouraging collagen and elastin production
Improving hydration at a cellular level by increasing hyaluronic acid synthesis
Reducing inflammation and oxidative stress, promoting skin healing
Enhancing skin tone, texture, and elasticity over time
Unlike traditional dermal fillers which simply add volume, polynucleotides focus on restoring skin quality from within. The result? Smoother, firmer, brighter, and more youthful-looking skin with a natural finish.
Ideal For:
Fine lines and wrinkles
Dull, tired, or crepey skin
Under-eye rejuvenation and dark circles
Scarring or acne scarring
Skin affected by sun damage or stress
Those seeking a more natural approach to skin regeneration
Polynucleotide treatments can be used as a standalone skin booster or combined with other aesthetic treatments like microneedling for enhanced results. They're suitable for all skin types and are especially popular for delicate areas like the tear troughs and neck.
Polynucleotide Skin Regeneration Treatments
Reveal healthier, firmer, and more radiant skin with our advanced polynucleotide therapy. We offer three of the most trusted and clinically effective options: Vitaran®, Plinest® by Mastelli, and NEWEST® by Mastelli.
What Are Polynucleotides?
Polynucleotides (PNs) are purified fragments of DNA that stimulate your skin’s natural repair processes. Derived from salmon DNA and processed to the highest medical standards, these molecules promote:
- Deep hydration
- Collagen and elastin stimulation
- Tissue repair and regeneration
- Brighter, firmer, and more youthful skin
Unlike fillers, PNs don’t just “fill”—they regenerate. Ideal for anyone wanting a natural, glowing result with minimal downtime.
Vitaran®
Vitaran® is a next-generation polynucleotide treatment designed to renew and revitalise the skin from within. With ultra-purified salmon DNA fragments, Vitaran® enhances skin function at the cellular level.
Key benefits:
- Stimulates collagen and elastin for firmer skin
- Improves tone, texture, and hydration
- Safe for all skin types, including sensitive skin
- Especially effective for under-eye, face, and neck rejuvenation
Best results are seen with a course of treatments, spaced 2–3 weeks apart.
Plinest®
Plinest® is one of the most clinically studied and trusted polynucleotide products in regenerative aesthetics. Developed in Italy using PN-HPT™ technology, it is known for its superior skin repair and anti-inflammatory properties.
Ideal for:
- Tear troughs and fine lines
- Acne scarring or post-inflammatory marks
- Sensitive, inflamed, or stressed skin
- Enhancing results of microneedling, PRP, or laser
Plinest® is often considered the gold standard in skin regeneration, with visible improvement in skin quality, smoothness, and elasticity.
NEWEST® by Mastelli
NEWEST® is a cutting-edge polynucleotide-based injectable developed by Mastelli, the creators of Plinest. It combines polynucleotides with hyaluronic acid and amino acids to provide intensive skin regeneration, hydration, and bio-restructuring.
Key benefits:
- Combines polynucleotides with HA for superior hydration
- Stimulates collagen and elastin production
- Improves skin elasticity, texture, and firmness
- Ideal for the face, neck, and décolletage
This treatment is excellent for those seeking comprehensive skin rejuvenation, particularly in areas showing early signs of ageing or loss of elasticity.
Which Treatment Is Right for Me?
Vitaran, Plinest, and NEWEST® all offer powerful skin regeneration. The best option depends on your individual concerns, skin condition, and treatment goals. During your consultation, we will create a tailored treatment plan to achieve optimal results.
Results improve over time, and most clients complete a series of 3–4 treatments for the best outcome.
Our services.
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Polynucleotide Under Eyes
Polynucleotide injections using Vitaran or Plinest target the under-eye area to deeply hydrate, repair, and improve skin quality. Helps reduce dark circles, fine lines, and puffiness while boosting collagen and tissue regeneration.
Per session: £200
3 session: £450
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Polynucleotides Full Face
Polynucleotide injections for the full face using Vitaran or Plinest help stimulate collagen production, improve skin hydration, and reduce fine lines. This treatment enhances skin texture and firmness, leaving the face looking rejuvenated and refreshed.
Per session with Vitaran: £350
Per session with Plinest: £375
3 sessions with Vitaran : £800
3 sessions with Plinest: £900
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Polynucleotides Full Face & Neck
Polynucleotide injections for the full face and neck using Vitaran or Plinest help stimulate collagen production, improve skin hydration, and reduce fine lines. This treatment enhances skin texture and firmness, leaving the face looking rejuvenated and refreshed.
SINGLE SESSION
Per session with Vitaran: £425
Per session with Plinest: £450
PACKAGES
3 sessions with Vitaran: £1000
3 sessions with Plinest: £1100
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Polynucleotides Neck Only
Polynucleotide injections using Vitaran or Plinest for the neck area help improve skin hydration, stimulate collagen production, and reduce the appearance of fine lines. This treatment enhances skin elasticity and texture, promoting a smoother, firmer, and rejuvenated neckline.
SINGLE SESSION
Per session with Vitaran®: £275
Per session with Plinest®: £300
PACKAGES
3 sessions with Vitaran®: £650
3 sessions with Plinest®: £750
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Newest® by Mastelli - Polynucleotide + Hyaluronic Acid Skin Booster - Full Face
Newest® is an advanced injectable polynucleotide gel formulated by Mastelli, combining highly‑purified PN‑HPT™ (polynucleotides), hyaluronic acid, and mannitol. It stimulates fibroblast activity, boosts collagen and elastin production, and enhances hydration and elasticity. Clinically supported to improve skin radiance, reduce fine lines and acne scarring, and repair texture irregularities.
Full Face
SINGLE SESSION
Per session: £300
PACKAGES
3 sessions: £700
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Newest® by Mastelli - Polynucleotide + Hyaluronic Acid Skin Booster - Full Face & Neck
Newest® is an advanced injectable polynucleotide gel formulated by Mastelli, combining highly‑purified PN‑HPT™ (polynucleotides), hyaluronic acid, and mannitol. It stimulates fibroblast activity, boosts collagen and elastin production, and enhances hydration and elasticity. Clinically supported to improve skin radiance, reduce fine lines and acne scarring, and repair texture irregularities.
Full Face & Neck
SINGLE SESSION
Per session: £400
PACKAGES
3 sessions: £950
Combinations
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Polynucleotides Under Eye + Microneedling Full Face w/Mesotherapy Ampoule
Combine Polynucleotides under eyes with Microneedling w/ Mesotherapy ampoule for a comprehensive approach to treating your skin.
For more information on Microneedling w/Mesotherapy ampoule click here.
SINGLE SESSION
Per session: £300
PACKAGES
3 sessions: £700
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Polynucleotides Under Eye + Microneedling Full Face w/ VTECH Exosomes + Polynucleotides
Combine Polynucleotides under eyes with Microneedling w/ Exosomes+ Polynucleotides for a comprehensive approach to treating your skin.
For more information on Microneedling with/Exosomes+Polynucleotides click here.
SINGLE SESSION
Per session: £350
PACKAGES
3 sessions: £800
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Polynucleotides Under Eye + Microneedling w/PRP Full Face
A powerful combination treatment targeting under-eye rejuvenation and full-face renewal. Polynucleotides restore and hydrate the eye area, while microneedling with PRP boosts collagen and improves skin texture, tone, and radiance.
SINGLE SESSION
Per session: £350
PACKAGES
3 sessions: £750
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Polynucleotides Under Eye + Microneedling w/PRP Full Face & Neck
A powerful combination treatment targeting under-eye rejuvenation and full-face renewal. Polynucleotides restore and hydrate the eye area, while microneedling with PRP boosts collagen and improves skin texture, tone, and radiance.
SINGLE SESSION
Per session: £375
PACKAGE
3 sessions: £850
Injectable Skin Boosters
Skin boosters are an advanced injectable treatment designed to hydrate, rejuvenate, and improve the overall appearance of the skin. Made from hyaluronic acid or polynucleotides, these treatments help restore moisture, enhance skin elasticity, and promote a natural glow. Unlike traditional dermal fillers, skin boosters are injected into the skin’s deeper layers, providing long-lasting hydration and improving skin texture.
The treatment works by stimulating collagen production, which results in smoother, more youthful-looking skin. Skin boosters are ideal for individuals looking to enhance skin quality, reduce fine lines, and combat dryness. They can be used on various areas of the face, neck, décolletage, and hands.
At Virgo & Co. Skin and Aesthetics, we offer polynucleotide skin boosters, which help repair and regenerate the skin, leaving you with revitalized, plump, and glowing skin.
Profhilo & Seventy Hyal Skin Boosters
Explore two of the most advanced injectable treatments designed to hydrate, firm, and revitalise your skin.
What is Profhilo?
Profhilo is an advanced injectable skin treatment that delivers deep hydration and improves skin texture and tone. It contains high concentrations of hyaluronic acid (HA) but is not a volumising filler. Instead, it enhances overall skin quality, leaving it smoother, firmer, and more radiant.
How Does Profhilo Work?
Profhilo is injected into the deeper layers of the skin where it stimulates collagen and elastin production. It spreads beneath the skin to create long-lasting hydration and promote tissue remodeling. Ideal for the face, neck, hands, and décolletage, especially in skin showing early signs of ageing.
Key Benefits of Profhilo
- Intense hydration and smoother skin
- Stimulates collagen and elastin naturally
- Non-volumising, subtle enhancement
- Refreshed, youthful results
Profhilo Treatment Process
Profhilo is usually done over two sessions, spaced 4 weeks apart. The injections are quick, with minimal discomfort. Results begin to appear within a few days, with full effects visible in a few weeks and lasting up to 6 months.
What is Seventy Hyal?
Seventy Hyal is a next-generation skin booster that combines high molecular weight hyaluronic acid with complex ingredients to deliver intense hydration and visible skin rejuvenation. It improves firmness, elasticity, and skin texture while reducing fine lines.
How Does Seventy Hyal Work?
Seventy Hyal is injected directly into the skin where it binds moisture, providing a plump, hydrated appearance. It also stimulates the body’s natural production of collagen and elastin, helping to firm and strengthen the skin over time. It’s ideal for the face, neck, hands, and décolletage.
Key Benefits of Seventy Hyal
- Deep, long-lasting hydration
- Boosts collagen and elastin production
- Smooths fine lines and improves tone
- Natural-looking results lasting 9–12 months
Seventy Hyal Treatment Process
Seventy Hyal is administered via a series of small injections. The procedure is quick and minimally uncomfortable, with little to no downtime. Mild redness or swelling may occur but usually resolves within a few hours. Results develop over several days and improve with time.
Skin Booster Price List
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Profhilo Full Face
Per session: £250
2 sessions: £450
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Profhilo Full Face & Neck
Per session: £400
2 sessions: £700
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Polynucleotides Under Eye & Profhilo Full Face
Per session: £400
2 sessions: £700
Including Neck Profhilo or Polynucleotides
Per session: £550
2 sessions: £950
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Seventy Hyal 2000 Full Face
A full course of Seventy Hyal 2000 consists of 3 treatment sessions, each spaced 4 weeks apart. One session may not achieve desired results.
Per session: £200
3 sessions: £450
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Seventy Hyal 200 Full Face & Neck
A full course of Seventy Hyal 2000 consists of 3 treatment sessions, each spaced 4 weeks apart. One session may not achieve desired results.
Per session: £250
3 sessions: £550
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Polynucleotides Under Eye & Seventy Hyal Full Face
A full course of Seventy Hyal 2000 consists of 3 treatment sessions, each spaced 4 weeks apart. One session may not achieve desired results. Included under eye polynucleotides simultaneously target under eye concerns
Per session: £300
3 sessions: £700
Including neck Seventy Hyal or Polynucleotides
Per session: £350
3 session: £800
Sunekos Skin Booster
Sunekos is a cutting-edge injectable treatment designed to restore hydration, elasticity, and overall skin health using a combination of hyaluronic acid and six essential amino acids.
What is Sunekos?
Sunekos is an advanced injectable skin booster combining hyaluronic acid with six essential amino acids to stimulate collagen and elastin production. It improves hydration, firmness, and elasticity while maintaining a natural, refreshed look.
How Does Sunekos Work?
Sunekos works in two ways:
- Hydration: Hyaluronic acid attracts and locks in moisture, plumping the skin.
- Biostimulation: Amino acids fuel fibroblasts to produce new collagen and elastin, improving structure and elasticity.
Key Benefits
- Deep hydration and visible plumpness
- Boosts collagen and elastin naturally
- Reduces fine lines, wrinkles, and crepey texture
- Improves skin tone, elasticity, and radiance
- Provides subtle, natural-looking rejuvenation
- Minimal downtime, gentle procedure
Treatment Protocol
A typical course includes 3–4 sessions spaced 1–2 weeks apart. Results begin to appear within days, with full effects after 4–6 weeks. Effects last 6–9 months, with maintenance recommended every 6–12 months.
Who Is Sunekos For?
Sunekos is ideal for clients who want natural skin regeneration without adding volume, and is especially effective for:
- Fine lines, early ageing or mild laxity
- Dry, dull, or crepey-textured skin
- Under-eye hollows, neck, décolletage or hands
Sunekos
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Sunekos Under Eye
Per session: £200
3 sessions: £450
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Sunekos Full Face
Per session: £350
3 sessions: £800
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Sunekos Full Face & Neck
Per session: £450
3 sessions: £950
Jalupro
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Jalupro Young Eye
Per session: £200
3 sessions: £450
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Jalupro Super Hydro Full Face
Per session: £250
3 sessions: £600
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Jalupro Super Hydro Full Face & Neck
Per session: £350
3 sessions: £850